Publications

A Role for the RNA Polymerase Gene Specificity Factor σ⁵⁴ in the Uniform Colony Growth of Uropathogenic Escherichia coli.

Switzer A, Burchell L, Mitsidis P, Thurston T, Wigneshweraraj S.

2022, J Bacteriol. Apr 19;204(4):e0003122. doi: 10.1128/jb.00031-22. 

Pneumolysin suppresses the initial macrophage pro-inflammatory response to Streptococcus pneumoniae.

Periselneris J, Turner CT, Ercoli G, Szylar G, Weight CM, Thurston T, Whelan M, Tomlinson G, Noursadeghi M, Brown J.

2022, Immunology. Jul 14. doi: 10.1111/imm.13546. 

Editorial: Bacterial Effectors as Drivers of Human Disease: Models, Methods, Mechanisms

Gunnar N Schroeder, Jaclyn S Pearson, Teresa LM Thurston

2021, Frontiers in Cellular and Infection Microbiology, Jul 8;11:708228.

TIRAP in the Mechanism of Inflammation.

Rajpoot S, Wary KK, Ibbott R, Liu D, Saqib U, Thurston TLM, Baig MS.

2021, Front Immunol. Jul 8;12:697588. 

TPL-2 kinase induces phagosome acidification to promote macrophage killing of bacteria

Breyer F, Hartlova A, Thurston T, Flynn HR, Chakravarty P, Janzen J, Peltier J, Heunis T, Snijders AP, Trost M, Ley SC

2021, EMBO JOURNAL, ISSN: 0261-4189

Interesting biochemistries in the structure and function of bacterial effectors

Mak H, Thurston T

2021, Frontiers in Cellular and Infection Microbiology, Vol: 11, ISSN: 2235-2988

Salmonella-driven polarization of granuloma macrophages antagonizes TNF-mediated pathogen restriction during persistent infection

Pham THM, Brewer SM, Thurston T, Massis LM, Honeycutt J, Lugo K, Jacobson AR, Vilches-Moure JG, Hamblin M, Helaine S, Monack DM

2020, Cell Host and Microbe, Vol: 27, Pages: 54-67.E5, ISSN: 1931-3128

Salmonella effector SteE converts the mammalian serine/threonine kinase GSK3 into a tyrosine kinase to direct macrophage polarization.

Panagi I, Jennings E, Zeng J, Günster RA, Stones CD, Mak H, Jin E, Stapels DAC, Subari NZ, Pham THM, Brewer SM, Ong SYQ, Monack DM, Helaine S, Thurston TLM

2020, Cell Host and Microbe, Vol: 27, Pages: 41-53.e6, ISSN: 1931-3128

Salmonella persisters undermine host immune defenses during antibiotic treatment

Stapels DAC, Hill PWS, Westermann AJ, Fisher RA, Thurston TL, Saliba A-E, Blommestein I, Vogel J, Helaine S

2018,  Science, Vol: 362, Pages: 1156-1160, ISSN: 0036-8075

Structure-function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-B

Jennings E, Esposito D, Rittinger K, Thurston TLM

2018, Journal of Biological Chemistry, Vol: 293, Pages: 15316-15329, ISSN: 0021-9258

Methylthioadenosine suppresses Salmonella virulence

Bourgeois JS, Zhou D, Thurston TLM, Gilchrist JJ, Ko DC

2018 Infection and Immunity, Vol: 86, ISSN: 0019-9567

Structural basis for the glycosyltransferase activity of the Salmonella effector SseK3 

Esposito D, Günster RA, Martino L, El Omari K, Wagner A, Thurston TLM, Rittinger K

2018, Journal of Biological Chemistry, Vol: 293, Pages: 5064-5078, ISSN: 0021-9258

Salmonella SPI-2 Type III Secretion System Effectors: Molecular Mechanisms And Physiological Consequences

Jennings E, Thurston TLM, Holden DW

2017, CELL HOST & MICROBE, Vol: 22, Pages: 217-231, ISSN: 1931-3128

SseK1 and SseK3 Type III Secretion System Effectors Inhibit NF-kappa B Signaling and Necroptotic Cell Death in Salmonella-Infected Macrophages  

Gunster RA, Matthews SA, Holden DW, Thurston TLM

2017, Infection and Immunity, Vol: 85, ISSN: 0019-9567

TBK1 directs WIPI2 against Salmonella

Boyle KB, Thurston TLM, Randow F

2016, Autophagy, Vol: 12, Pages: 2508-2509, ISSN: 1554-8627

Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death

Thurston T, Matthews S, Jennings E, Alix E, Shao F, Shenoy A, Birrell M, Holden D

2016, Nature Communications, Vol: 7, ISSN: 2041-1723

Recruitment of TBK1 to cytosol‐invading Salmonella induces WIPI2‐dependent antibacterial autophagy

Thurston TL, Boyle KB, Allen M, Ravenhill BJ, Karpiyevich M, Bloor S, Kaul A, Noad J, Foeglein A, Matthews SA, Komander D, Bycroft M, Randow F

2016, EMBO Journal, Vol: 35, Pages: 1779-1792, ISSN: 0261-4189

Cytosolic Replication of Group A Streptococcus in Human Macrophages

O’Neill A, Thurston T, Holden D

2016, mBio, Vol: 7, ISSN: 2161-2129

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ, et al.,

2016, Autophagy, Vol: 12, Pages: 1-215, ISSN: 1554-8635

Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins

Boname JM, Bloor S, Wandel MP, Nathan JA, Antrobus R, Dingwell KS, Thurston TL, Smith DL, Smith JC, Randow F, Lehner PJ

2014, J Cell Biol, Vol: 205, Pages: 847-862

Salmonella inhibits retrograde trafficking of mannose-6-phosphate receptors and lysosome function

McGourty K, Thurston TLM, Matthews SA, Pinaud L, Mota LJ, Holden DW

2012, Science, Dec 7;338(6112):1287

Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion

Thurston TLM, Wandel MP, von Muhlinen N, Foeglein A, Randow F

2012, Nature, Vol: 482, Pages: 414-418, ISSN: 0028-0836

NDP52, a novel autophagy receptor for ubiquitin-decorated cytosolic bacteria

von Muhlinen N, Thurston T, Ryzhakov G, Bloor S, Randow F

2010, AUTOPHAGY, Vol: 6, Pages: 288-+, ISSN: 1554-8627

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria.

Thurston TLM, Ryzhakov G, Bloor S, von Muhlinen N, Randow F

2009, Nature Immunology volume 10, pages 1215–1221