We collaborate with several labs. This is so we can share our expertise and also benefit from the expertise of others.
Dr. Katrin Rittinger
We’ve been collaborating on the structural biology of Salmonella effectors since 2018. Katrin is co-investigator on our recently awarded MRC research grant and so we are excited to carry on collaborating on new projects that start in October 2021.
Prof. Steve Ley
We share a passion for kinase signaling and innate immunity with the Ley lab and when we can combine this with bacteria it is even better. We recently worked with the Ley lab to analyse how Tpl2 kinase promotes macrophage killing of bacteria. See their paper here.
Prof. Tom Ellis
Tom is a PI at Imperial College, in synthetic biology. He does some really cool stuff, which you can read about here. Tom and I have a new collaboration, co-supervising a graduate student called Alison. Together we want to engineer bacteria, including Salmonella, to target tumours.
Prof. Denise Monack
The Monack lab are experts in studying the mechanisms of persistent bacterial infection, pathogen transmission, and host immunity. They also share our love for studying Salmonella and the effector SteE. In 2020, in a back-to-back publication with our own work on SteE, they published how SteE helps neutralize the effects of TNF, shifting granuloma macrophages toward an M2 state and helping increase bacterial persistence in vivo.
Dr. Sophie Helaine
When the Helaine lab were based at the CMBI we used to share a floor and lab meetings as well as our interest in Salmonella. Through these interactions, we came to understand how the Salmonella effector SteE is linked to macrophage polarisation and persistence.
Prof. David Holden
David pioneered studies into the SPI-2-encoded T3SS secretion system of Salmonella. He continues to be a legend in all things Salmonella related and we have the great pleasure of sharing a lab space with his lab as well as group meetings.